In his book, Albert Hoffman described how he came to Sandoz in 1929 after completing his PhD, and in 1935 began working on ergotamine and the newly-isolated lysergic acid which was derived from it. ... and in 1938 synthesized LSD 25.
He decided to study the drug and ingested .25 mgm. He then described his terrifying experience. "Even worse than the demonic transformations of the outer world, were the alterations that I perceived in myself, in my inner being. Every exertion of my will, every attempt to put an end to the disintegration of the outer world and the dissolution of my ego, seemed to be wasted effort.
Thus, although overwhelmed by his experience...of the "disintegration of the world and the dissolution of his ego," Hoffman twisted his experience into a positive one. He extolled the experience, claimed it was mind-expanding, and ignored its severe pathological effects on his mind.
He became an active, articulate proselyte for LSD.. attracted many supporters including Alduous Huxley, Timothy Leary, and Alan Ginsburg. They organized marches and gatherings, proclaimed, "tune in, turn on, drop out" joyfully, and were oblivious to the damage they were causing in others and in themselves.